How do you titrate Remodulin?
Start your patient at a dose of 1.25 ng/kg/min. Titrate up in 1.25 ng/kg/min increments per week to achieve a dose that improves PAH symptoms while minimizing excessive pharmacologic effects of Remodulin (ie, headache, nausea, emesis, restlessness, anxiety, and infusion site pain or reaction).
Is Remodulin a continuous infusion?
Remodulin is indicated for subcutaneous (SC) or intravenous (IV) use only as a continuous infusion. Remodulin is preferably infused subcutaneously, but can be administered by a central intravenous line if the subcutaneous route is not tolerated because of severe site pain or reaction.
What is the half life of Remodulin?
Excretion: The elimination of Remodulin is biphasic, with a terminal half-life of approximately 4 hours. Approximately 79% of an administered dose is excreted in the urine as unchanged drug (4%) and as the identified metabolites (64%). Approximately 13% of a dose is excreted in the feces.
How much is a bottle of remodulin?
The cost for Remodulin injectable solution (1 mg/mL) is around $1,350 for a supply of 20 milliliters, depending on the pharmacy you visit….Injectable Solution.
| Quantity | Per unit | Price |
|---|---|---|
| 20 milliliters | $335.68 | $6,713.53 |
Is remodulin covered by Medicare?
*Flolan, Ventavis, Remodulin and Tyvaso are generally covered under Medicare Part B because of the use of durable medical equipment when administered.
How long does it take for Remodulin to work?
Another effectiveness measure was whether Remodulin could reduce patients’ shortness of breath, assessed by the Borg dyspnea score. The therapy improved patients’ performance on both measures after 12 weeks, compared with the placebo group.
Does remodulin cause loss of appetite?
SIDE EFFECTS: Nausea, vomiting, diarrhea, headache, dizziness, jaw pain, flushing, loss of appetite, weakness, abdominal pain, and redness/swelling/pain at the injection site may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Does remodulin make you tired?
Treprostinil helps to improve symptoms such as shortness of breath and tiredness. It works by relaxing and widening the blood vessels (arteries) in the lungs and other parts of the body so that blood can flow more easily.
What happens if you stop taking remodulin?
Stopping the medication: Stopping treprostinil abruptly or sudden large decreases in the dose can result in symptoms of pulmonary hypertension such as pain when breathing (dyspnea), dizziness, weakness, and fatigue.
How is the rate of Remodulin administered?
Remodulin is administered by subcutaneous or intravenous infusion at a calculated rate based on a patient’s dose (ng/kg/min), weight (kg) and the Remodulin concentration (mg/mL). For administration of Undiluted Remodulin the rate is calculated using the following formula:
What is the optimal dose of Remodulin for hepatic insufficiency?
In patients with mild or moderate hepatic insufficiency, decrease the initial dose of Remodulin to 0.625 ng/kg/min ideal body weight.
Can Remodulin be used in an infusion pump?
*Undiluted Remodulin can also be used for IV administration in the CADD-MS® 3 ambulatory infusion pump along with appropriate anticoagulation. †Conversion factor of 0.00006 = 60 min/hour x 0.000001 mg/ng.
How much Remodulin do you give a Pah patient?
Start your patient at a dose of 1.25 ng/kg/min. Titrate up in 1.25 ng/kg/min increments per week to achieve a dose that improves PAH symptoms while minimizing excessive pharmacologic effects of Remodulin (ie, headache, nausea, emesis, restlessness, anxiety, and infusion site pain or reaction). 1