What are the side effects of telithromycin?
Common side effects of Ketek include:
- nausea,
- vomiting,
- mild diarrhea,
- headache,
- anxiety,
- a strange taste in the mouth, or.
- vaginal itching or discharge.
What is the main indication of telithromycin?
KETEK is indicated for the treatment of community-acquired pneumonia (of mild to moderate severity) due to Streptococcus pneumoniae, (including multi-drug resistant S. pneumoniae [MDRSP1]), Haemophilus influenzae, Moraxella catarrhalis, Chlamydophila pneumoniae, or Mycoplasma pneumoniae, for patients 18 years or older.
What is telithromycin used to treat?
Telithromycin is used to treat a lung infection called community-acquired pneumonia (CAP). It belongs to the family of medicines called antibiotics. Antibiotics are medicines used in the treatment of infections caused by bacteria. They work by killing bacteria or preventing their growth.
What is the brand name for telithromycin?
Telithromycin is the first ketolide antibiotic to enter clinical use and is sold under the brand name of Ketek. It is used to treat community acquired pneumonia of mild to moderate severity.
How is telithromycin excreted?
After entering the systemic circulation, telithromycin is eliminated by multiple pathways (7% by biliary and/or intestinal excretion, 13% by renal excretion and 37% by hepatic metabolism). Telithromycin is metabolised via cytochrome P450 (CYP) 3A4 and non-CYP pathways.
How does telithromycin work?
Telithromycin is in a class of medications called ketolide antibiotics. It works by killing bacteria. Antibiotics such as telithromycin not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.
What is the risk of telithromycin associated liver failure?
Mild and anicteric cases of liver injury attributed to telithromycin have been reported, but some cases are very severe and associated with rapid development of hepatic failure with ascites and hepatic encephalopathy. Eosinophilia and rash can occur, but are not common.
What type of antibiotic is telithromycin?
Telithromycin is in a class of medications called ketolide antibiotics. It works by killing bacteria. Antibiotics such as telithromycin not work for colds, flu, or other viral infections.
Is sulfamethoxazole hard on liver?
Sulfamethoxazole/Trimethoprim (SMX/TMP) is a commonly used antibiotic, its’ known adverse reaction of hepatotoxicity leading to acute liver failure is considered rare.
Does co trimoxazole cause liver damage?
Hepatotoxicity with elevated liver enzymes is a well-known side effect of co-trimoxazole. Other reports have associated the drug with cholestatic liver disease9, 10 and pancreatitis,11, 12, 13 and rarely a vanishing bile duct syndrome following the administration of co-trimoxazole9, 14 has been described.
Can Bactrim cause hepatotoxicity?
Bactrim is known for its potential to cause idiosyncratic liver injury that has features of drug-allergy or hypersensitivity. The pattern of injury is typically cholestatic or mixed and can be prolonged. This case represents a rare occurrence of Bactriminduced hepatotoxicity.
Can sulfamethoxazole cause liver damage?
The sulfamethoxazole component of SMX/TMP is responsible for most of its’ side effects including liver failure. Although Trimethoprim alone can be used for treatment of uncomplicated UTI[1], SMX/TMP is commonly used for that purpose in the United States for unclear reasons.
Is cotrimoxazole good for liver?
Abstract. Trimethoprim-sulfamethoxazole (co-trimoxazole) is used extensively for treatment of pulmonary and urinary tract infections. Side effects may affect skin, blood, bone marrow, kidney and the liver.
Does Bactrim cause hepatotoxicity?
The hepatotoxicity seen with the use Bactrim is from the sulfamethoxazole component and results in a cholestatic or mixed pattern, as seen in this case. Treatment is supportive care and withdrawal of the medication. Extensive hepatic injury with liver failure may result in the need for liver transplant.
Is septra hepatotoxic?
Sulfonamides (applies to Septra DS) liver disease Major Potential Hazard, Moderate plausibility. Hepatotoxicity, including jaundice, diffuse hepatocellular necrosis, hypersensitivity hepatitis and hepatic failure, has rarely been reported in patients receiving sulfonamides.
Is Bactrim hepatotoxic?
Is Bactrim safe for the liver?
Can you take azithromycin with liver problems?
Azithromycin is primarily excreted by the hepatobiliary system. Although the drug is generally well-tolerated and associated with few adverse effects, therapy with azithromycin should be administered cautiously in patients with liver and/or biliary disease.
Can Zpack cause liver damage?
In rare cases, common drugs such as Z-Paks, prescribed to fight illnesses, can harm the liver. A U-M patient and liver specialist explain. In 2009, Eric Barth arrived at an emergency department in Kalamazoo, Michigan, with the typical symptoms of pneumonia.
Does telithromycin cause drug-induced liver injury?
Conclusion: Telithromycin is a rare cause of drug-induced liver injury that may have a distinctive clinical signature and associated high mortality rate. Consensus for attribution of liver injury to a selected drug exposure by individual experts can be aided by careful definition of terminology and discussion.
Telithromycin is used to treat a lung infection called community-acquired pneumonia (CAP). It belongs to the family of medicines called antibiotics. Antibiotics are medicines used in the treatment of infections caused by bacteria.
Where can I get information about telithromycin (naproxen)?
1 Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA. [email protected] Telithromycin is the first of a new class of ketolide antibiotics with increased activity against penicillin-resistant and erythromycin-resistant pneumococci.